Therapeutic Advances and Treatment Options in Metastatic Melanoma
نویسندگان
چکیده
منابع مشابه
Treatment options for metastatic melanoma in solid organ transplant recipients
CTLA: cytotoxic T-lymphocyteeassociated protein 4 FDA: US Food and Drug Administration IFN-a: interferon alfa MAPK: mitogen-activated protein kinase PD-1: programmed death-1 SOTRs: solid organ transplant recipients INTRODUCTION Solid organ transplant recipients (SOTRs) have a 2.4-fold increased risk for melanoma. Renal transplant recipients have an incidence of melanoma up to 8 times greater th...
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Despite advances in treatment and surveillance, melanoma continues to claim approximately 9,000 lives in the US annually (SEER 2013). The National Comprehensive Cancer Network currently recommends ipilumumab, vemurafenib, dabrafenib, and high-dose IL-2 as first line agents for Stage IV melanoma. Little data exists to guide management of cutaneous and subcutaneous metastases despite the fact tha...
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Prior to 2011, the only commercially available agents commonly used to treat metastatic melanoma-including dacarbazine, temozolomide (Temodar), fotemustine, carboplatin, paclitaxel, and interleukin-2-demonstrated limited efficacy, and no study involving these agents had shown an improvement in overall survival. The standard of care for the treatment of metastatic melanoma was radically changed ...
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BACKGROUND Patients who develop metastatic melanoma often have limited effective treatment options. However, a select group of patients will benefit from aggressive surgery or a multidisciplinary approach, depending on the site of metastasis. METHODS The current literature was reviewed and summarized regarding the collective recommendations for staging and treating patients with metastatic me...
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ژورنال
عنوان ژورنال: JAMA Oncology
سال: 2015
ISSN: 2374-2437
DOI: 10.1001/jamaoncol.2015.0565